Nosocomial infections due to multi-drug resistant strains appear to be a particular problem in our settings, though the extent of this remains poorly manage. In developing countries, neonatal infections cause about 1,600,000 deaths per year. Most common type of antibiotics resistance among pathogens is due to the production of ?-lactamases genes which are encoded either on plasmids or chromosomes such as extended spectrum-?-lactamases, metallo-?-lactamases, carbapenamases and New Delhi metallo-?-lactamases. Reports of multi-drug resistant bacteria causing neonatal septicemia in developing countries are increasing particularly in intensive care units. Multi-drug resistant pathogens causing neonatal septicemia are the leading cause of neonatal morbidity and mortality worldwide. To reduce global neonatal mortality, the introduction of effective... The main cause is the wide availability of over the counter antibiotics and the inappropriate use of broad spectrum antibiotics in the community.